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        FAS antibody, FAS抗體

         
        編 號 PR-1042
        產品名稱 FAS antibody, FAS抗體
        規 格 0.2ml
        價 格 1980元
        應 用 IHC,WB,ELISA,ICC,IP,IF
        品 牌 Hopebiot

        詳細信息: 說明書下載

        Background:  FAS is a receptor for TNFSF6/FASL. The adaptor molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Apoptosis or programmed-cell death is a physiological process essential for the normal development and maintenance of homeostasis in many organisms. This “cellular suicide” can be mediated by the Fas antigen (CD95, APO1), a cell-surface glycoprotein, 40-50kDa, that belongs to the nerve growth factor/tumor necrosis factor (TNF) receptor family. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity). It is type I membrane protein. Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adaptor proteins Contains 1 death domain.

        Description: Rabbit polyclonal to FAS

        Immunogen: KLH conjugated synthetic peptide derived from FAS

        Specificity:  ·Reacts with Human, Mouse and Rat.

        ·Isotype: IgG

        Application:  ·Western blotting: 1/100-500. Predicted Mol wt: 45 kDa;

        ·Immunohistochemistry (Paraffin/frozen tissue section): 1/50-200;

        ·Immunocytochemistry/Immunofluorescence: 1/100;

        ·Immunoprecipitation: 1/50;

        ·ELISA: 1/500;

        ·Optimal working dilutions must be determined by the end user.

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